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Centre for Ophthalmology, University Eye Hospital, Tübingen, Germany

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Full member

HCP Center

The University Eye Hospital provides health care in all areas of ophthalmology at highest quality level with more than 60.000 consultations of patients and more than 13.000 surgeries annually. In close cooperation with the Institute for Ophthalmic Research, it develops novel therapeutic approaches for diseases of the eye.

The Centre for Ophthalmology of the University Hospital Tübingen is the largest and one of the most important centres for ophthalmology in Germany and pioneers in research and clinical work. It is heavily involved in many current developments in the field of ophthalmology. The Centre for Ophthalmology consists of the University Eye Hospital and the Institute for Ophthalmic Research.

The University Eye Hospital covers and treats a wide spectrum of ophthalmological diseases including trauma. It possesses a leading position in health care and research. The Institute for Ophthalmic Research, founded in 2007, concentrates on degenerative, inflammatory, neoplastic, and vascular diseases of the eye and the visual pathways at a molecular, cellular and systemic level.

Picture : Aspiriniks

Contact

Centre for Ophthalmology, University Eye Hospital, Tübingen, Germany

Department für Augenheilkunde Tübingen Forschungsinstitut für Augenheilkunde Elfriede-Aulhorn-Str. 7
72076 Tübingen
Germany

Team

Pr Katarina Stingl

Representative

Germany

Low Vision Daily Life and Patients Groups (TWG5), Registries & Epidemiology (TWG7), Research (TWG8), Retinal Rare Eye Diseases (WG1)
Working Group Leader
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Dr Susanne KOHL

Substitute

Germany

Genetic Diagnostics (TWG6), Registries & Epidemiology (TWG7), Research (TWG8), Retinal Rare Eye Diseases (WG1)
Working Group Leader
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Prof. Dr. med. Karl Ulrich Bartz-Schmidt

Substitute

Germany

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M.Sc. Melanie Kempf

Germany

Low Vision Daily Life and Patients Groups (TWG5), Retinal Rare Eye Diseases (WG1)
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Dr Thomas Wheeler-Schilling

Germany

National Integration (TWG9)
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Clinical trials

NCT05537220 - Active, Not recruiting

NAC Attack, A Phase III, Multicenter, Randomized, Parallel, Double Masked, Placebo-Controlled Study Evaluating the Efficacy and Safety of Oral N-Acetylcysteine in Patients With Retinitis Pigmentosa

Interventional
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NCT05158296 - Active, Not recruiting

A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety and Tolerability of Ultevursen in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene (Sirius)

Interventional
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NCT05176717 - Terminated

A Double-Masked, Randomized, Controlled, Multiple-Dose Study to Evaluate the Efficacy, Safety and Tolerability of QR-421a in Subjects With Retinitis Pigmentosa (RP) Due to Mutations in Exon 13 of the USH2A Gene With Early to Moderate Vision Loss

Interventional
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NCT04855045 - Unknown

An Open-Label, Dose Escalation and Double-Masked, Randomized, Controlled Study to Evaluate the Safety and Tolerability of Sepofarsen in Pediatric Subjects G (p.Cys998X) Mutation.

Interventional
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NCT03001310 - Completed

An Open Label, Multi-centre, Phase I/II Dose Escalation Trial of a Recombinant Adeno-associated Virus Vector (AAV2/8-hCARp.hCNGB3) for Gene Therapy of Adults and Children With Achromatopsia Owing to Defects in CNGB3

Interventional
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NCT05566795 - Recruiting, Active

A Phase 3, Randomized, International Multicenter Trial of DAY101 Monotherapy Versus Standard of Care Chemotherapy in Patients with Pediatric Low-Grade Glioma Harboring an Activating RAF Alteration Requiring First-Line Systemic Therapy

Interventional
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NCT04967287 - Active, Not recruiting

MyopiaX Treatment for the Reduction of Myopia Progression in Children and Adolescents: Safety and Efficacy Investigation

Interventional
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EST_2 - NCT01837901 - Completed

Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa.

Interventional
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NCT01835002 - Completed

This is a single-arm open label interventional safety trial with RP patients, who receive weekly TES for 6 months on 1 eye followed by observation for another 6 months without stimulation. The primary outcome measure is safety, indicated by the frequency and severity of adverse events.

Interventional
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NCT04127006 - Active, Not recruiting

Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS).

Observational
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NCT04611503 - Active, Not recruiting

PIGMENT – PDE6A gene therapy for retinitis pigmentosa.

Interventional
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NCT03913143 - Active, Not recruiting

A double-masked, randomized, controlled, multiple-dose study to evaluate the efficacy, safety, tolerability and systemic exposure of QR-110 in Subjects with Leber’s Congenital Amaurosis (LCA) due to c.2991+1655A>G mutation (p.Cys998X) in the CEP290 gene (Illuminate).

Interventional
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NCT03507686 - Completed

An Open-Label Safety Study of Retinal Gene Therapy for Choroideremia with Bilateral,Sequential Administration of Adeno-Associated Viral Vector (AAV2) Encoding Rab Escort Protein 1 (REP1).

Interventional
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NCT03359551 - Completed

Natural History of the Progression of Choroideremia Study NSR-CHM-OS1.

Observational
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NCT03584165 - Recruiting, Active

A Long-term Follow-up Study to Evaluate the Safety and efficacy of Retinal Gene Therapy in Subjects with choroideremia treated previously with Adeno-Associated Viral Vector Encoding Rab Escort Protein-1 (AAV2-REP1) in an Antecedent Study.

Interventional
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2013-005393-22 - Completed

A Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin : Retinol Acyltransferase (LRAT).

Interventional
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NCT02771379 - Completed

A Non-interventional Study of Clinical Experience in Patients Prescribed Raxone® for the Treatment of Leber’s Hereditary Optic Neuropathy (LHON).

Observational
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NCT02671539 - Completed

Tübingen Choroideremia gene therapy trial open label Phase 2 clinical trial using anadeno-associated viral vector (AAV2) encoding Rab-escort protein 1 (REP1)

Interventional
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NCT02575430 - Completed

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT.

Observational
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NCT02610582 - Recruiting, Active

Safety and efficacy of a single subretinal injection of rAAV.hCNGA3 in patients with CNGA3-linked achromatopsia investigated in an exploratory, dose-escalation trial.

Interventional
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NCT02410122 - Completed

The Natural History of the Progression of Atrophy Secondary to Stargardt Disease Type 4: PROM1-Related Macular Dystrophy (ProgStar-4).

Observational
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NCT05811351 - Recruiting, Active

A Phase 2b, Randomized, Double-masked, Multicenter, Dose-ranging, Sham-controlled Clinical Trial to Evaluate Intravitreal JNJ-81201887 (AAVCAGsCD59) Compared to Sham Procedure for the Treatment of Geographic Atrophy (GA) Secondary to Age-related Macular Degeneration (AMD)

Interventional
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NCT03364153 - Active, Not recruiting

A Phase 2b Randomized, Double-masked, Controlled Trial to Establish the Safety and Efficacy of Zimura™ (Complement C5 Inhibitor) Compared to Sham in Subjects With Autosomal Recessive Stargardt Disease

Interventional
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NCT04435366 - Completed

A Phase 3 Multicenter, Randomized, Double Masked, Sham- Controlled Clinical Trial to Assess the Safety and Efficacy of Intravitreal Administration of Zimura (Complement C5 Inhibitor) in Patients With Geographic Atrophy Secondary to Age-Related Macular Degeneration

Interventional
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DRKS00023562 - Recruiting, Active

Evaluation of the effectiveness of transcorneal electrostimulation in patients with retinitis pigmentosa - a multicenter, prospective, randomized, controlled and double-blind study on behalf of the G-BA

Interventional
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NCT00515814 - Completed

Retina Implant Pilot Trial to Evaluate Safety & Efficacy in Blind Patients HavingDegenerated Photo-receptors

Interventional
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NCT01024803 - Completed

Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients.

Interventional
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NCT01521793 - Completed

Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis orRetinitis Pigmentosa (Extension of Study RET IRD 01)

Interventional
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NCT02759952 - Recruiting, Active

Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparationto a Gene Therapy Trial

Observational
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NCT04639635 - Recruiting, Active

Study of CNGB1 Retinitis Pigmentosa and Allied Hereditary Disorders

Observational
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NCT04765345 - Active, Not recruiting

Rate of Progression of PCDH15-Related Retinal Degeneration in Usher

Observational
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NCT04926129 - Completed

Natural history of the progression of X-linked retinitis pigmentosa.

Observational
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NCT04983914 - Completed

Retrospective Non-Interventional Study to Evaluate the Patient Benefit of Transcorneal Electrostimulation (TES)

Observational
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NCT04939571 - Recruiting, Active

European Disease Registry on Retinopathy of Prematurity (ROP)

Observational
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NCT04965038 - Recruiting, Active

Early Reperfusion Therapy With Intravenous Alteplase for Recovery of VISION in Acute Central Retinal Artery Occlusion

Interventional
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NCT04924608 - Not recruiting, Inactive

A Phase III, Multicentre, International Study With a Parallel, Randomised, Double-blind, Placebo-controlled, 2 Arm Design to Assess the Efficacy and Safety of Selumetinib in Adult Participants With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas (KOMET)

Interventional
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