Clinical Trial
A double-masked, randomized, controlled, multiple-dose study to evaluate the efficacy, safety, tolerability and systemic exposure of QR-110 in Subjects with Leber’s Congenital Amaurosis (LCA) due to c.2991+1655A>G mutation (p.Cys998X) in the CEP290 gene (Illuminate).
Disease
Disease type
Paediatric clinical trials
Orphan drug recognition
No
Patient type
Adult
Children
Inclusion / Exclusion
Funding
industry
Members involved
Others investigators

Pr Bart LEROY
Belgium

Pr Elfride DE BAERE
Belgium

Pr Carel HOYNG
Netherlands

Pr Dr Markus Preising
Germany

Pr Katarina Stingl
Germany

Pr Isabelle Audo
France

Pr Hélène Dollfus
France

Dr Ingeborgh VAN DEN BORN
Netherlands
ERN EYE member investigating site
HCP : Principal investigators

Ghent University Hospital, Ghent, Belgium
Adress
Corneel Heymanslaan 10
9000 Ghent
Belgium

Radboud university medical center, Nijmegen, Netherlands
Adress
Geert Grooteplein Zuid 10
6525 GA Nijmegen
Netherlands

Universitätsklinikum Gießen und Marburg GmbH, Gießen, Germany
Adress
Klinik und Poliklinik für Augenheilkunde Friedrichstr. 18
35392 Gießen
Germany

Centre for Ophthalmology, University Eye Hospital, Tübingen, Germany
Adress
Department für Augenheilkunde Tübingen Forschungsinstitut für Augenheilkunde Elfriede-Aulhorn-Str. 7
72076 Tübingen
Germany

CARGO, Hôpitaux Universitaires de Strasbourg, France
Adress
Hôpital Civil -Bâtiment du Centre de Recherche en Biomédecine de Strasbourg (CRBS),1 Rue Eugène Boeckel
67000 STRASBOURG
France

RÉFÉRET National Hospital of Ophthalmology of Quinze-Vingts, Paris, France
Adress
28 Rue de Charenton
75012 Paris
France

The Rotterdam Eye Hospital, Rotterdam, Netherlands
Adress
Schiedamse Vest 180
3011 BH Rotterdam
Netherlands

Erasmus MC: University Medical Center Rotterdam, Netherlands
Adress
Doctor Molewaterplein 40
3015 GD Rotterdam
Netherlands