Clinical trials ongoing in ERN-EYE Members Expertise Centers

by Disease

 You can click on the title of the trial to open a description of the trial

 

Choroideremia 

A Multicenter Prospective Observational "Natural History" Study in Patients With Choroideremia (choroideremia)

CIL 34546-NSR-REP-01 (Choroideremia)

SOLSTICE (Choroideremia)

STAR (Choroideremia)

NIGHT (Choroideremia)

GEMINI (Choroideremia)

THOR (Choroideremia (phenotype + approved molecular diagnosis))

 

Retinitis pigmentosa

A Dose Escalation, Phase 1/2 Clinical Trial of Retinal Gene Therapy for X-linked Retinitis Pigmentosa Using an Adeno-Associated Viral Vector (AAV8) Encoding Retinitis Pigmentosa GTPase Regulator (RPGR)

XOLARIS - Natural history of the progression of X-linked retinitis pigmentosa (X-linked retinitis pigmentosa, Germany)

XOLARIS - Natural history of the progression of X-linked retinitis pigmentosa (X-linked retinitis pigmentosa, France)

XOLARIS- Natural history of the progression of X-linked retinitis pigmentosa (X-linked retinitis pigmentosa, UK)

XIRIUS (X-linked RP)

Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) (Retinitis pigmentosa, Usher Syndrome)

Retinitis pigmentosa: molecular diagnosis by next generation sequencing (inherited retinal dystrophy)

Therapeutic management of patients with cystoid macular edema secondary (retinitis pigmentosa)

Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) (Retinitis pigmentosa; Inherited Retinal Disease caused by Mutation in RPE65 or LRAT genes)

VITAL (USHER syndrome induced by MYO7A mutation and retinotosis pigmentosa)

Argus® II Retinal Stimulation System Feasibility Protocol (retinotosis pigmentosa)

Argus® II Retinal Prosthesis System: Post-Market Study (retinotosis pigmentosa)

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B (Retinitis Pigmentosa Associated With Usher Syndrome Type 1B)

Clinical implication of Retinitis Pigmentosa molecular diagnostic using high throughput sequencing (RP-SEQ-HD)

Safety and Efficacy of a Unilateral Subretinal Administration of HORA-PDE6B in Patients With Retinitis Pigmentosa Harbouring Mutations in the PDE6B Gene Leading to a Defect in PDE6B Expression

Study to Evaluate Safety and Tolerability of QR-421a in Subjects With Retinitis Pigmentosa Due to Mutations in Exon 13 of the USH2A Gene (Stellar)

Dose-escalation Study to Evaluate the Safety and Tolerability of GS030 in Subjects With Retinitis Pigmentosa (PIONEER)

 

Leber syndrome

An open label dose escalation clinical trial to evaluate the safety and the tolerability of gs010 (Leber hereditary optic neuropathy)

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation (RESCUE) (Leber hereditary optic neuropathy)

Non-interventional Study of Clinical Experience in Patients Prescribed Raxone® for the Treatment of Leber's Hereditary Optic Neuropathy (LHON) (Leber's Hereditary Optic Neuropathy)

REVERSE (Leber hereditary optic neuropathy (LHON))

Historical Case Record Survey of Visual Acuity Data From Patients With Leber’s Hereditary Optic Neuropathy (LHON)

Efficacy and safety of QLT091001 in subjects with Inherited Retinal Disease (IRD) caused by gene mutations

NCT03913143 - ILLUMINATE

Observational Registry Study of Leber Hereditary Optic Neuropathy (LHON) Affected Patients

Efficacy & Safety Study of Bilateral Intravitreal Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)

 

Neurotrophic Keratitis

Evaluation of safety and efficacy of r-hNGF (Neurotrophic Keratitis)

 

Stargardt Disease

Natural History of the Progression of Atrophy Secondary (Stargardt Disease type 4)

Phase I/IIa Study of SAR422459 in Patients With Stargardt's Macular Degeneration (Stargardt's disease)

A Study to Determine the Long Term Safety, Tolerability and Biological Activity of SAR422459 in Patients With Stargardt's Macular Degeneration (Stargardt's disease)

Therapeutic Potential of Omega-3 Fatty Acids Supplementation in Dry Macular Degeneration and Stargardt Disease (MADEOS)

 

Hereditary retinal disease

CURETINA (hereditary retinal degenerations caused by mutations in genes CRB1, CRX, PROM1)

RET-IRD-04 (LCA RPE65)

ReCOVER (This trial does use Clemastine fumarat as a remyelinating agent targeting the muscarinic receptor on oligodendrocytes around the optic nerve)

 

CNGA3-linked achromatopsia

CNGA3 (CNGA3-linked achromatopsia)

 

Argus II

Argus II retinal prosthesis system post- market surveillance study protocol (inherited retinal dystrophy & choroidal dystrophy)

Argus® II Retinal Stimulation System Feasibility Protocol (retinotosis pigmentosa)

Argus® II Retinal Prosthesis System: Post-Market Study (retinotosis pigmentosa)

 

Glaucoma

Long-Term Non-Interventional Latanoprost Study (LYNX) (congenital glaucoma)

 

Usher Syndrome

VITAL (USHER syndrome induced by MYO7A mutation and retinotosis pigmentosa)

Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) (Retinitis pigmentosa, Usher Syndrome)

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B (Retinitis Pigmentosa Associated With Usher Syndrome Type 1B)

Open-Label Study to Determine the Long-Term Safety, Tolerability and Biological Activity of UshStat® in Patients With Usher Syndrome Type 1B (Usher Syndrome)

Light4deaf study: study of the natural history of the syndrome of usher in a cohort of patients followed longitudinally for 5 years  (Usher Syndrome)

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B (Retinitis Pigmentosa Associated With Usher Syndrome Type 1B)

Study to Evaluate Safety and Tolerability of QR-421a in Subjects With Retinitis Pigmentosa Due to Mutations in Exon 13 of the USH2A Gene (Stellar)

  

Chorioretinopathy

SPECTRA trial (central serous chorioretinopathy)

 

Retinal dystrophy

Compensation for blindness with the Intelligent Retinal Implant System (IRIS V2) (retinal dystrophy)

Nanometer-controlled cut-off filters in real-life self-reported quality of vision of patients with retinitis pigmentosa (inherited retinal dystrophy)

Riluzole in patients with spinocerebellar ataxia type 7: a randomized, double-blind, placebo-controlled pilot trial with a lead in phase

Natural History Study of CEP290-Related Retinal Degeneration

 

Congenital cataract registry

Factors affecting sight development in congenital cataract patients (congenital cataract registry)

  

Alström Syndrome

Clinical Study of a single ciliopathy: Alström Syndrome

 

Trisomy 21

Trisomy 21 in Adulthood : a medical and social situation in Alsace

 

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