Clinical trials ongoing in ERN-EYE Members Expertise Centers

NCT01496040

Retinitis Pigmentosa, Pediatric clinical trials

Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65

Leber Congenital Amaurosis

Skin-to-Eye Study

NCT03359551

Choroideremia

Night

2013-005393-22

Retinitis Pigmentosa, Pediatric clinical trials

A Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin : Retinol Acyltransferase (LRAT)

NCT03975543

Retinitis Pigmentosa, Pediatric clinical trials

PHENOROD1

NCT02671539

Choroideremia

THOR

NCT02994368

Choroideremia, Pediatric clinical trials

A Multicenter Prospective Observational « Natural History » Study in Patients With Choroideremia

RET RP 01 - NCT01543906

Retinitis Pigmentosa

Oral QLT091001 in Retinitis Pigmentosa (RP) Subjects With an Autosomal Dominant Mutation in Retinal Pigment Epithelial 65 Protein (RPE65)

NCT04127006

Retinitis Pigmentosa

Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS)

NCT02720640

Retinitis Pigmentosa

Safety and Efficacy of the Alpha AMS Subretinal Implant

NCT02110225

Retinitis Pigmentosa

LUMOS

NCT01876147

Retinitis Pigmentosa

Visual and Functional Assessment in Low Vision Patients

NCT03490019

Bardet-Biedl, Pediatric clinical trials

BBS

NCT03561922

Hereditary retinal disease

Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS

NCT04405882

Hereditary retinal disease

Cornea Ectasia Excimer Laser Treatment

NCT02771236

Hereditary retinal disease, Pediatric clinical trials

Clinical and Molecular Studies in Families With Inherited Eye Disease

NCT03662386

Hereditary retinal disease, Pediatric clinical trials

GEPHIRD

NCT03772665

Stargardt Disease, Pediatric clinical trials

SeaSTAR

NCT01496040

Leber Congenital Amaurosis, Pediatric clinical trials

Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65

NCT03913143

Leber Congenital Amaurosis, Pediatric clinical trials

ILLUMINATE

NCT03116113

Retinitis Pigmentosa, Pediatric clinical trials

XIRIUS

Leber Congenital Amaurosis

GENPHENACL

NCT01521793

Retinitis Pigmentosa, Leber Congenital Amaurosis, Pediatric clinical trials

RET IRD 02

NCT02575430

Leber Congenital Amaurosis, Pediatric clinical trials

RET NAT 01

EST_2 - NCT01837901

Retinitis Pigmentosa

Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa

NCT02410122

Stargardt Disease

PROGSTAR-4 STUDY

NCT02890550

Alström Syndrome, Pediatric clinical trials

Clinical Study of a single ciliopathy: Alström Syndrome

NCT03746522

Bardet-Biedl, Alström Syndrome, Pediatric clinical trials

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Patients With Moderate to Severe Obesity

NCT03496012

Choroideremia

STAR

NCT02860520

Retinitis Pigmentosa, Pediatric clinical trials

Clinical implication of Retinitis Pigmentosa molecular diagnostic using high throughput sequencing (RP-SEQ-HD)

NCT01461213

Choroideremia

CIL 34546-NSR-REP-01

NCT01505062

Retinitis Pigmentosa, Usher Syndrome, Pediatric clinical trials

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B

NCT02759952

Retinitis Pigmentosa

Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial

NCT01835002

Retinitis Pigmentosa

TESOLA

PROST

Retinitis Pigmentosa

Validation of standardized test protocols to assess the impact of visual pathologies in daily life activities

PASS

Retinitis Pigmentosa, Pediatric clinical trials

A Post-Authorization, Multicenter, Multinational, Longitudinal,Observational Safety Registry Study for Patients Treated with Voretigene Neparvovec

PROMA

Retinitis Pigmentosa

Design of a mobility protocol allowing to assess the impact of visual pathologies in activities of daily living for subjects with advanced visual deficits

NCT00515814

Retinitis Pigmentosa

Retina Implant Pilot Trial to Evaluate Safety & Efficacy in Blind Patients Having Degenerated Photo-receptors

NCT03963154

Retinitis Pigmentosa

STREAM

NCT03326336

Retinitis Pigmentosa

PIONEER

NCT03780257

Retinitis Pigmentosa

STELLAR

NCT03510234

Other

Self-confidence Study in Patients With Argus II Artificial Retina

NCT01490827

Other

Argus II retinal prosthesis system post-market surveillance study protocol (Argus II PM-01-01)

NCT04128150

Other, Pediatric clinical trials

High Resolution Retina Imaging (IHR)

CURETINA

Hereditary retinal disease, Pediatric clinical trials

CURETINA

NCT00643747

Leber Congenital Amaurosis

Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis

RET-IRD-04

Leber Congenital Amaurosis

RET-IRD-04

NCT03140969

Leber Congenital Amaurosis, Pediatric clinical trials

Study to Evaluate QR-110 in Subjects With Leber’s Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

LIGHT4DEAF

Usher Syndrome, Pediatric clinical trials

LIGHT4DEAF

NCT01024803

Retinitis Pigmentosa

Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients

NCT01235624

Retinitis Pigmentosa, Pediatric clinical trials

Autosomal Dominant Retinitis Pigmentosa: Prevalence of Known Genes Identification of New Loci / Genes

VITAL

Retinitis Pigmentosa, Pediatric clinical trials

VITAL

NCT01469832

Stargardt Disease

Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt’s Macular Dystrophy (SMD)

NCT01367444

Stargardt Disease

Phase I/IIa Study of SAR422459 in Patients With Stargardt’s Macular Degeneration

VITAL

Usher Syndrome, Pediatric clinical trials

VITAL

NCT02065011

Usher Syndrome

An Open-Label Study to Determine the Long-Term Safety, Tolerability and Biological Activity of UshStat® in Patients With Usher Syndrome Type 1B

NCT01954953

Usher Syndrome, Pediatric clinical trials

EURUSH

NCT00213811

Bardet-Biedl

Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in Adults

NCT01793090

Other, Pediatric clinical trials

EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment

NCT03297515

Stargardt Disease

MADEOS

NCT03507686

Choroideremia

Gemini

NCT03584165

Choroideremia

SOLSTICE

RSFVEN-330/2010-BIS

Retinitis Pigmentosa

Therapeutic management of patients with cystoid macular edema secondary to retinitis pigmentosa

DIIO_EPPR_P13_03

Retinitis Pigmentosa, Pediatric clinical trials

Retinitis pigmentosa: molecular diagnosis by next generation sequencing

EudraCT 2016-003705-34

Retinitis Pigmentosa

PIGMENT – PDE6A gene therapy for retinitis pigmentosa

NCT04285398

Retinitis Pigmentosa

PHENOROD2

NCT02610582

CNGA3-linked achromatopsia

CNGA3

NCT03319849

Other, Pediatric clinical trials

A Study to Determine the Safety and Efficacy of Renexus® in Macular Telangiectasia Type 2

NCT03940690

Other, Pediatric clinical trials

COATS-VEGF

NCT00481546

Hereditary retinal disease, Pediatric clinical trials

LCA

RSFVEN-330/2010-TRIS

Retinitis Pigmentosa

Nanometer-controlled cut-off filters in real-life self-reported quality of vision of patients with retinitis pigmentosa

NCT01736592

Stargardt Disease

A Study to Determine the Long Term Safety, Tolerability and Biological Activity of SAR422459 in Patients With Stargardt’s Macular Degeneration

NCT03913130

Leber Congenital Amaurosis, Pediatric clinical trials

INSIGHT

NCT00422721

Leber Congenital Amaurosis

Genetic Study of Patients Suffering From Congenital Amaurosis of Leber or From an Early Severe Retinal Dystrophy

TESOLAUK - NCT01847365

Retinitis Pigmentosa

TES for the Treatment of Retinitis Pigmentosa (RP)

NCT00407602

Other, Pediatric clinical trials

Argus® II Retinal Stimulation System Feasibility Protocol

NCT03146078

Retinitis Pigmentosa, Usher Syndrome, Pediatric clinical trials

RUSH2A

REGENERATE - NCT02407678

Choroideremia

REP1 Gene Replacement Therapy for Choroideremia

NCT02303288

Other

Argus® II Retinal Prosthesis System: Post-Market Study

NCT03780257

Usher Syndrome

STELLAR

NCT00407602

Retinitis Pigmentosa, Pediatric clinical trials

Argus® II Retinal Stimulation System Feasibility Protocol

NCT03314207

Retinitis Pigmentosa

XOLARIS

NCT03328130

Retinitis Pigmentosa

Safety and Efficacy of a Unilateral Subretinal Administration of HORA-PDE6B in Patients With Retinitis Pigmentosa Harbouring Mutations in the PDE6B Gene Leading to a Defect in PDE6B Expression

NCT03814499

Usher Syndrome, Pediatric clinical trials

Natural History Study in Subjects With Usher Syndrome

NCT03079141

Chorioretinopathy, Pediatric clinical trials

SPECT

NCT02521311

Hereditary retinal disease

RECOVER

NCT01265719

Glaucoma, Pediatric clinical trials

LYNX

NCT02176733

Leber Hereditary Optic Neuropathy (LHON)

CICLO-NOHL

NCT01522638

Other, Pediatric clinical trials

ADOA

NCT02771379

Leber Hereditary Optic Neuropathy (LHON)

PAROS

NCT02064569

Leber Hereditary Optic Neuropathy (LHON)

An open label dose escalation clinical trial to evaluate the safety and the tolerability of gs010 (rAAV2/2-ND4) in patients with leber hereditary optic neuropathy due to mutations in the mitochondrial nadh dehydrogenase 4 gene

NCT01892943

Leber Hereditary Optic Neuropathy (LHON), Pediatric clinical trials

Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey

NCT02544217

Leber Hereditary Optic Neuropathy (LHON)

A Phase I, Randomized, Double Blind, Placebo-controlled, Dose-escalating Clinical Trial With KH176

NCT03293524

Leber Hereditary Optic Neuropathy (LHON)

REFLECT

NCT02796274

Leber Hereditary Optic Neuropathy (LHON), Pediatric clinical trials

Historical Case Record Survey of Visual Acuity Data From Patients With Leber’s Hereditary Optic Neuropathy (LHON)

NCT04561466

Leber Hereditary Optic Neuropathy (LHON)

BÉFINOHL

NCT03295071

Leber Hereditary Optic Neuropathy (LHON), Pediatric clinical trials

REALITY

NCT02652767

Leber Hereditary Optic Neuropathy (LHON)

RESCUE

NCT02652780

Leber Hereditary Optic Neuropathy (LHON), Pediatric clinical trials

REVERSE

NCT03717909

Wolfram, Pediatric clinical trials

Efficacy and Safety Trial of Sodium Valproate, in Paediatric and Adult Patients With Wolfram Syndrome

NCT02521311

Hereditary retinal disease

RECOVER

NCT03406104

Leber Hereditary Optic Neuropathy (LHON), Pediatric clinical trials

RESCUE/REVERSE

NCT03847272

Uveitis

USTEKINISU

NCT03308045

Uveitis

Evaluation of EYS606 in Patients With Non-infectious Posterior, Intermediate or Panuveitis

NCT01756456

Other

REPARO

NCT01295164

Keratoconus

VOPTICA

NCT03661164

Keratoconus, Pediatric clinical trials

Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients

Congenital cataract registry, Pediatric clinical trials

Longitudinal observation of factors affecting sight development in congenital cataract patients, long term observation of IOL implantation outcomes.

NCT03464994

Other

ICHTYO-KERATO

NCT03753009

Keratoconus, Pediatric clinical trials

Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up.

NCT04517903

Keratoconus, Pediatric clinical trials

Validation Study on Eye Rubbing Questionnaire in Patients With or Suspected of Having a Keratoconus (KC) (QFK)

NCT03584243

Keratoconus

TE-CXL