Clinical trials ongoing in ERN-EYE Members Expertise Centers

REGENERATE - NCT02407678

REP1 Gene Replacement Therapy for Choroideremia

Choroideremia

NCT02671539

THOR

Choroideremia

NCT03496012

STAR

Choroideremia

NCT01461213

CIL 34546-NSR-REP-01

Choroideremia

NCT03507686

Gemini

Choroideremia

NCT03584165

SOLSTICE

Choroideremia

NCT03359551

Night

Choroideremia

NCT02994368

A Multicenter Prospective Observational « Natural History » Study in Patients With Choroideremia

Choroideremia

RSFVEN-330/2010-TRIS

Nanometer-controlled cut-off filters in real-life self-reported quality of vision of patients with retinitis pigmentosa

Hereditary retinal disease

NCT00481546

LCA

Hereditary retinal disease

NCT03662386

GEPHIRD

Hereditary retinal disease

NCT02771236

Clinical and Molecular Studies in Families With Inherited Eye Disease

Hereditary retinal disease

NCT01490827

Argus II retinal prosthesis system post-market surveillance study protocol (Argus II PM-01-01)

Hereditary retinal disease

RECOVER

RECOVER

Hereditary retinal disease

CURETINA

CURETINA

Hereditary retinal disease

NCT04405882

Cornea Ectasia Excimer Laser Treatment

Hereditary retinal disease

NCT03561922

Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS

Hereditary retinal disease

NCT03146078

RUSH2A

Retinitis Pigmentosa

NCT00407602

Argus® II Retinal Stimulation System Feasibility Protocol

Retinitis Pigmentosa

NCT03780257

STELLAR

Retinitis Pigmentosa

NCT02759952

Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial

Retinitis Pigmentosa

NCT01876147

Visual and Functional Assessment in Low Vision Patients

Retinitis Pigmentosa

PROST

Validation of standardized test protocols to assess the impact of visual pathologies in daily life activities

Retinitis Pigmentosa

NCT03326336

PIONEER

Retinitis Pigmentosa

NCT02110225

LUMOS

Retinitis Pigmentosa

NCT03314207

XOLARIS

Retinitis Pigmentosa

PROMA

Design of a mobility protocol allowing to assess the impact of visual pathologies in activities of daily living for subjects with advanced visual deficits

Retinitis Pigmentosa

NCT02575430

Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT

Retinitis Pigmentosa

NCT04285398

PHENOROD2

Retinitis Pigmentosa

NCT03975543

PHENOROD1

Retinitis Pigmentosa

VITAL

VITAL

Retinitis Pigmentosa

NCT02303288

Argus® II Retinal Prosthesis System: Post-Market Study

Retinitis Pigmentosa

NCT01835002

TESOLA

Retinitis Pigmentosa

NCT01024803

Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients

Retinitis Pigmentosa

PASS

A Post-Authorization, Multicenter, Multinational, Longitudinal,Observational Safety Registry Study for Patients Treated with Voretigene Neparvovec

Retinitis Pigmentosa

NCT03116113

XIRIUS

Retinitis Pigmentosa

NCT01505062

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B

Retinitis Pigmentosa

NCT03963154

STREAM

Retinitis Pigmentosa

NCT03328130

Safety and Efficacy of a Unilateral Subretinal Administration of HORA-PDE6B in Patients With Retinitis Pigmentosa Harbouring Mutations in the PDE6B Gene Leading to a Defect in PDE6B Expression

Retinitis Pigmentosa

NCT00515814

Retina Implant Pilot Trial to Evaluate Safety & Efficacy in Blind Patients Having Degenerated Photo-receptors

Retinitis Pigmentosa

NCT02860520

Clinical implication of Retinitis Pigmentosa molecular diagnostic using high throughput sequencing (RP-SEQ-HD)

Retinitis Pigmentosa

NCT01235624

Autosomal Dominant Retinitis Pigmentosa: Prevalence of Known Genes Identification of New Loci / Genes

Retinitis Pigmentosa

RSFVEN-330/2010-BIS

Therapeutic management of patients with cystoid macular edema secondary to retinitis pigmentosa

Retinitis Pigmentosa

DIIO_EPPR_P13_03

Retinitis pigmentosa: molecular diagnosis by next generation sequencing

Retinitis Pigmentosa

NCT01521793

RET IRD 02

Retinitis Pigmentosa

NCT02720640

Safety and Efficacy of the Alpha AMS Subretinal Implant

Retinitis Pigmentosa

EST_2 - NCT01837901

Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa

Retinitis Pigmentosa

Pro-EYS - NCT04127006

Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS)

Retinitis Pigmentosa

TESOLAUK - NCT01847365

TES for the Treatment of Retinitis Pigmentosa (RP)

Retinitis Pigmentosa

EudraCT 2016-003705-34

PIGMENT – PDE6A gene therapy for retinitis pigmentosa

Retinitis Pigmentosa

RET RP 01 - NCT01543906

Oral QLT091001 in Retinitis Pigmentosa (RP) Subjects With an Autosomal Dominant Mutation in Retinal Pigment Epithelial 65 Protein (RPE65)

Retinitis Pigmentosa

NCT01496040

Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65

Retinitis Pigmentosa

2013-005393-22

A Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin : Retinol Acyltransferase (LRAT)

Retinitis Pigmentosa

NCT01736592

A Study to Determine the Long Term Safety, Tolerability and Biological Activity of SAR422459 in Patients With Stargardt’s Macular Degeneration

Stargardt Disease

NCT03297515

MADEOS

Stargardt Disease

NCT02410122

PROGSTAR-4 STUDY

Stargardt Disease

NCT01367444

Phase I/IIa Study of SAR422459 in Patients With Stargardt’s Macular Degeneration

Stargardt Disease

NCT03772665

SeaSTAR

Stargardt Disease

NCT02771379

PAROS

Stargardt Disease

NCT01469832

Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt’s Macular Dystrophy (SMD)

Stargardt Disease

NCT02771379

PAROS

Leber Hereditary Optic Neuropathy (LHON)

NCT03406104

RESCUE/REVERSE

Leber Hereditary Optic Neuropathy (LHON)

NCT02544217

A Phase I, Randomized, Double Blind, Placebo-controlled, Dose-escalating Clinical Trial With KH176

Leber Hereditary Optic Neuropathy (LHON)

NCT02176733

CICLO-NOHL

Leber Hereditary Optic Neuropathy (LHON)

NCT02652767

RESCUE

Leber Hereditary Optic Neuropathy (LHON)

NCT02064569

An open label dose escalation clinical trial to evaluate the safety and the tolerability of gs010 (rAAV2/2-ND4) in patients with leber hereditary optic neuropathy due to mutations in the mitochondrial nadh dehydrogenase 4 gene

Leber Hereditary Optic Neuropathy (LHON)

NCT03293524

REFLECT

Leber Hereditary Optic Neuropathy (LHON)

NCT02652780

REVERSE

Leber Hereditary Optic Neuropathy (LHON)

NCT03295071

REALITY

Leber Hereditary Optic Neuropathy (LHON)

NCT02796274

Historical Case Record Survey of Visual Acuity Data From Patients With Leber’s Hereditary Optic Neuropathy (LHON)

Leber Hereditary Optic Neuropathy (LHON)

NCT01892943

Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey

Leber Hereditary Optic Neuropathy (LHON)

NCT03079141

SPECTRA

Chorioretinopathy

NCT03140969

Study to Evaluate QR-110 in Subjects With Leber’s Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene

Leber Congenital Amaurosis

NCT03913143

ILLUMINATE

Leber Congenital Amaurosis

NCT03913130

INSIGHT

Leber Congenital Amaurosis

GENPHENACL

Leber Congenital Amaurosis

NCT00422721

Genetic Study of Patients Suffering From Congenital Amaurosis of Leber or From an Early Severe Retinal Dystrophy

Leber Congenital Amaurosis

RET-IRD-04

RET-IRD-04

Leber Congenital Amaurosis

NCT00643747

Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis

Leber Congenital Amaurosis

NCT01521793

RET IRD 02

Leber Congenital Amaurosis

NCT01496040

Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65

Leber Congenital Amaurosis

NCT02575430

RET NAT 01

Leber Congenital Amaurosis

Longitudinal observation of factors affecting sight development in congenital cataract patients, long term observation of IOL implantation outcomes.

Congenital cataract registry

NCT01756456

REPARO

Neurotrophic Keratitis

NCT02610582

CNGA3

CNGA3-linked achromatopsia

NCT01490827

Argus II retinal prosthesis system post-market surveillance study protocol (Argus II PM-01-01)

Argus II

NCT03510234

Self-confidence Study in Patients With Argus II Artificial Retina

Argus II

NCT00407602

Argus® II Retinal Stimulation System Feasibility Protocol

Argus II

NCT02303288

Argus® II Retinal Prosthesis System: Post-Market Study

Argus II

NCT01265719

LYNX

Glaucoma

NCT03780257

STELLAR

Usher Syndrome

VITAL

VITAL

Usher Syndrome

NCT02065011

An Open-Label Study to Determine the Long-Term Safety, Tolerability and Biological Activity of UshStat® in Patients With Usher Syndrome Type 1B

Usher Syndrome

NCT01954953

EURUSH

Usher Syndrome

NCT03814499

Natural History Study in Subjects With Usher Syndrome

Usher Syndrome

NCT03146078

RUSH2A

Usher Syndrome

LIGHT4DEAF

LIGHT4DEAF

Usher Syndrome

NCT03490019

BBS

Bardet-Biedl

NCT00213811

Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in Adults

Bardet-Biedl

NCT03746522

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Patients With Moderate to Severe Obesity

Bardet-Biedl

NCT02890550

Clinical Study of a single ciliopathy: Alström Syndrome

Alström Syndrome

NCT03746522

Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Patients With Moderate to Severe Obesity

Alström Syndrome

NCT03464994

ICHTYO-KERATO

Ichthyosis

NCT03753009

Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up.

Keratoconus

NCT01295164

VOPTICA

Keratoconus

TE-CXL - NCT03584243

Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus

Keratoconus

NCT03661164

Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients

Keratoconus

NCT01663675

Trisomy 21 in Adulthood : a medical and social situation in Alsace

Trisomy 21

NCT01793090

EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment

Other

NCT03940690

COATS-VEGF

Other

NCT01522638

ADOA

Other

NCT04129021

IMA-MODE

Other

NCT03319849

A Study to Determine the Safety and Efficacy of Renexus® in Macular Telangiectasia Type 2

Other

NCT04128150

High Resolution Retina Imaging (IHR)

Other