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Lopende klinische studies in expertise centra van leden van ERN-EYE, gesorteerd op ziekte

 You can click on the title of the trial to open a description of the trial

 

Choroideremia 

A Multicenter Prospective Observational "Natural History" Study in Patients With Choroideremia (choroideremia)

CIL 34546-NSR-REP-01 (Choroideremia)

SOLSTICE (Choroideremia)

STAR (Choroideremia)

NIGHT (Choroideremia)

GEMINI (Choroideremia)

THOR (Choroideremia (phenotype + approved molecular diagnosis))

 

Retinitis pigmentosa

Natural history of the progression of X-linked retinitis pigmentosa (xolaris) (X-linked retinitis pigmentosa)

XOLARIS (X-Linked Retinitis Pigmentosa)

Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) (Retinitis pigmentosa, Usher Syndrome)

Retinitis pigmentosa: molecular diagnosis by next generation sequencing (inherited retinal dystrophy)

Therapeutic management of patients with cystoid macular edema secondary (retinitis pigmentosa)

Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) (Retinitis pigmentosa; Inherited Retinal Disease caused by Mutation in RPE65 or LRAT genes)

VITAL (USHER syndrome induced by MYO7A mutation and retinotosis pigmentosa)

Argus® II Retinal Stimulation System Feasibility Protocol (retinotosis pigmentosa)

Argus® II Retinal Prosthesis System: Post-Market Study (retinotosis pigmentosa)

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B (Retinitis Pigmentosa Associated With Usher Syndrome Type 1B)

Clinical implication of Retinitis Pigmentosa molecular diagnostic using high throughput sequencing (RP-SEQ-HD)

 

LHON: Leber's opticusatrofie

An open label dose escalation clinical trial to evaluate the safety and the tolerability of gs010 (Leber hereditary optic neuropathy)

Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation (RESCUE) (Leber hereditary optic neuropathy)

Non-interventional Study of Clinical Experience in Patients Prescribed Raxone® for the Treatment of Leber's Hereditary Optic Neuropathy (LHON) (Leber's Hereditary Optic Neuropathy)

REVERSE (Leber hereditary optic neuropathy (LHON))

Historical Case Record Survey of Visual Acuity Data From Patients With Leber’s Hereditary Optic Neuropathy (LHON)

 

Neurotrofe keratitis

Evaluation of safety and efficacy of r-hNGF (Neurotrophic Keratitis)

 

X-gebonden retinitis pigmentosa

Natural history of RPGR associated retinopathy (X-linked RP (RPGR))

XIRIUS (X-linked RP)

 

Ziekte van Stargardt

Natural History of the Progression of Atrophy Secondary (Stargardt Disease type 4)

Phase I/IIa Study of SAR422459 in Patients With Stargardt's Macular Degeneration (Stargardt's disease)

A Study to Determine the Long Term Safety, Tolerability and Biological Activity of SAR422459 in Patients With Stargardt's Macular Degeneration (Stargardt's disease)

 

Erfelijke netvliesaandoeningen

CURETINA (hereditary retinal degenerations caused by mutations in genes CRB1, CRX, PROM1)

RET-IRD-04 (LCA RPE65)

ReCOVER (This trial does use Clemastine fumarat as a remyelinating agent targeting the muscarinic receptor on oligodendrocytes around the optic nerve)

 

CNGA3-gebonden achromatopsie

CNGA3 (CNGA3-linked achromatopsia)

 

Argus II

Argus II retinal prosthesis system post- market surveillance study protocol (inherited retinal dystrophy & choroidal dystrophy)

Argus® II Retinal Stimulation System Feasibility Protocol (retinotosis pigmentosa)

Argus® II Retinal Prosthesis System: Post-Market Study (retinotosis pigmentosa)

 

Groene staar

Long-Term Non-Interventional Latanoprost Study (LYNX) (congenital glaucoma)

 

Ushersyndroom

VITAL (USHER syndrome induced by MYO7A mutation and retinotosis pigmentosa)

Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) (Retinitis pigmentosa, Usher Syndrome)

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B (Retinitis Pigmentosa Associated With Usher Syndrome Type 1B)

Open-Label Study to Determine the Long-Term Safety, Tolerability and Biological Activity of UshStat® in Patients With Usher Syndrome Type 1B (Usher Syndrome)

Prospective and comparative study of visual function in Usher type 1 syndrome caused by myosin VIIa gene mutations (MYO7A) and non-syndromic pigmentary retinopathy (Usher Syndrome and pigmentary retinopathy)

Light4deaf study: study of the natural history of the syndrome of usher in a cohort of patients followed longitudinally for 5 years  (Usher Syndrome)

Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B (Retinitis Pigmentosa Associated With Usher Syndrome Type 1B)

 

Corneatransplantatie

Multicenter, randomized, vehicle-controlled, double-masked clinical trial (Corneal graft rejection)

 

Chorioretinopathie

SPECTRA trial (central serous chorioretinopathy)

 

Retina dystrofie

Compensation for blindness with the Intelligent Retinal Implant System (IRIS V2) (retinal dystrophy)

Nanometer-controlled cut-off filters in real-life self-reported quality of vision of patients with retinitis pigmentosa (inherited retinal dystrophy)

Riluzole in patients with spinocerebellar ataxia type 7: a randomized, double-blind, placebo-controlled pilot trial with a lead in phase

 

Congenitaal cataract registratie

Factors affecting sight development in congenital cataract patients (congenital cataract registry)

  

Alströmsyndroom

Clinical Study of a single ciliopathy: Alström Syndrome

 

Trisomie 21

Trisomy 21 in Adulthood : a medical and social situation in Alsace

 

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