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Guidance on the management of clinical trials during the COVID-19 (coronavirus) pandemic
Choroideremia
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REP1 Gene Replacement Therapy for Choroideremia
212.26 Ko
24/07/2020
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STAR
233.50 Ko
12/11/2018
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A Multicenter Prospective Observational « Natural History » Study in Patients With Choroideremia
201.42 Ko
16/07/2020
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Gemini
203.60 Ko
16/07/2020
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A Randomised, Open Label, Outcomes-Assessor Masked, Prospective, Parallel Controlled Group, Phase 3 Clinical Trial Of Retinal Gene Therapy For Choroideremia Using An Adeno-Associated Viral Vector (AAV2) Encoding Rab Escort Protein 1 (REP1)
216.10 Ko
16/07/2020
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SOLSTICE
209.87 Ko
16/05/2019
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Night
216.60 Ko
16/07/2020
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CIL 34546-NSR-REP-01
212.57 Ko
16/05/2019
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THOR (Choroideremia (phenotype + approved molecular diagnosis))
221.28 Ko
21/06/2018
Retinitis Pigmentosa
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XIRIUS (X-linked RP)
211.63 Ko
16/05/2019
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Rate of Progression in USH2A Related Retinal Degeneration (RUSH2A) (Retinitis pigmentosa, Usher Syndrome)
231.16 Ko
16/05/2019
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Clinical implication of Retinitis Pigmentosa molecular diagnostic using high throughput sequencing (RP-SEQ-HD)
227.18 Ko
13/06/2018
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Therapeutic management of patients with cystoid macular edema secondary (retinitis pigmentosa)
252.80 Ko
16/05/2018
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Argus® II Retinal Stimulation System Feasibility Protocol (retinotosis pigmentosa) 2
212.46 Ko
09/07/2020
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Argus® II Retinal Prosthesis System: Post-Market Study
200.83 Ko
10/07/2020
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Study of the Efficacy and Safety of QLT091001 in Subjects with Inherited Retinal Disease (IRD) Caused by Mutation in Retinal Pigment Epithelium Protein 65 (RPE65) or Lecithin:Retinol Acyltransferase (LRAT) (Retinitis pigmentosa; Inherited Retinal Disease
222.87 Ko
16/05/2018
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Retinitis pigmentosa: molecular diagnosis by next generation sequencing (inherited retinal dystrophy)
251.00 Ko
16/05/2018
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Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B (Retinitis Pigmentosa Associated With Usher Syndrome Type 1B)
201.27 Ko
10/07/2020
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Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT
215.14 Ko
17/09/2020
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Oral QLT091001 in Retinitis Pigmentosa (RP) Subjects With an Autosomal Dominant Mutation in Retinal Pigment Epithelial 65 Protein (RPE65)
201.73 Ko
09/07/2020
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Clinical Characterization on PDE6A-related Retinitis Pigmentosa in Preparation to a Gene Therapy Trial
201.03 Ko
16/07/2020
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PIGMENT – PDE6A gene therapy for retinitis pigmentosa
200.91 Ko
20/07/2020
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TES for the Treatment of Retinitis Pigmentosa (RP)
209.43 Ko
20/07/2020
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Rate of Progression in EYS Related Retinal Degeneration (Pro-EYS)
214.02 Ko
29/06/2020
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Natural history of the progression of X-linked retinitis pigmentosa
514.39 Ko
09/07/2020
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Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa
199.06 Ko
16/07/2020
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Transcorneal Electrical Stimulation - Multicenter Safety Study
202.87 Ko
16/07/2020
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Safety and Efficacy of the Alpha AMS Subretinal Implant
199.51 Ko
24/07/2020
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Safety and Efficacy of a Unilateral Subretinal Administration of HORA-PDE6B in Patients With Retinitis Pigmentosa Harbouring Mutations in the PDE6B Gene Leading to a Defect in PDE6ß Expression
208.42 Ko
16/05/2019
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Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)
214.50 Ko
17/09/2020
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VITAL (USHER syndrome induced by MYO7A mutation and retinotosis pigmentosa)
239.78 Ko
05/07/2018
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Retrospective Natural History Study of Retinitis Pigmentosa Rare Eye
198.92 Ko
16/07/2020
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Prospective Natural History Study of Retinitis Pigmentosa (PHENOROD2
214.81 Ko
29/06/2020
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Autosomal Dominant Retinitis Pigmentosa: Prevalence of Known Genes Identification of New Loci / Genes
212.88 Ko
10/07/2020
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Validation of standardized test protocols to assess the impact of visual pathologies in daily life activities
212.48 Ko
29/06/2020
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A Post-Authorization, Multicenter, Multinational, Longitudinal,Observational Safety Registry Study for Patients Treated withVoretigene Neparvovec
199.94 Ko
29/06/2020
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Design of a mobility protocol allowing to assess the impact of visual pathologies in activities of daily living for subjects with advanced visual deficits
221.12 Ko
29/06/2020
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Safety and Efficacy of Subretinal Implants for Partial Restoration of Visionin Blind Patients
206.70 Ko
16/07/2020
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Retina Implant Pilot Trial to Evaluate Safety & Efficacy in Blind Patients Having Degenerated Photo-receptors
205.83 Ko
16/07/2020
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A Dose Ranging Study to Evaluate the Safety and Potential Efficacy of rhNGF in Patients With Retinitis Pigmentosa (RP)
208.35 Ko
20/07/2020
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Interventional Study of Implantation of hESC-derived RPE in Patients With RP Due to Monogenic Mutation
201.22 Ko
16/07/2020
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Dose-escalation Study to Evaluate the Safety and Tolerability of GS030 in Subjects With Retinitis Pigmentosa (PIONEER)
213.42 Ko
23/05/2019
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Study to Evaluate Safety and Tolerability of QR-421a in Subjects With Retinitis Pigmentosa Due to Mutations in Exon 13 of the USH2A Gene (Stellar)
211.63 Ko
23/05/2019
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Visual and Functional Assessment in Low Vision Patients
209.54 Ko
24/07/2020
Leber Hereditary Optic Neuropathy (LHON)
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Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey
201.15 Ko
10/07/2020
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Trial of Cyclosporine in the Acute Phase of Leber Hereditary Optic Neuropathy
199.37 Ko
10/07/2020
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Historical Case Record Survey of Visual Acuity Data From Patients With Leber’s Hereditary Optic Neuropathy (LHON) 2
229.60 Ko
16/07/2020
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A Phase I, Randomized, Double Blind, Placebo-controlled, Dose-escalating Clinical Trial With KH176
200.82 Ko
09/07/2020
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Observational Registry Study of Leber Hereditary Optic Neuropathy (LHON) Affected Patients
212.60 Ko
23/05/2019
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Non-interventional Study of Clinical Experience in Patients Prescribed Raxone® for the Treatment of Leber's Hereditary Optic Neuropathy (LHON) (Leber's Hereditary Optic Neuropathy)
224.43 Ko
16/05/2018
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REVERSE
212.38 Ko
16/05/2019
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Efficacy & Safety Study of Bilateral Intravitreal Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)
213.62 Ko
23/05/2019
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An open label dose escalation clinical trial to evaluate the safety and the tolerability of gs010 (rAAV2/2-ND4) in patients with leber hereditary optic neuropathy due to mutations in the mitochondrial nadh dehydrogenase 4 gene
201.31 Ko
10/07/2020
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Efficacy & Safety Study of Bilateral Intravitreal Injection of GS010 in LHON Subjects Due to the ND4 Mutation for up to 1 Year (REFLECT)
204.57 Ko
10/07/2020
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Efficacy Study of GS010 for the Treatment of Vision Loss up to 6 Months From Onset in LHON Due to the ND4 Mutation
202.35 Ko
02/09/2020
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RESCUE AND REVERSE
210.93 Ko
02/09/2020
Leber Congenital Amaurosis
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Natural History Study in Inherited Retinal Disease Subjects Caused by Mutations in RPE65 or LRAT
215.14 Ko
09/07/2020
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Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65
199.83 Ko
10/07/2020
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Repeated Treatments of QLT091001 in Subjects With Leber Congenital Amaurosis or Retinitis Pigmentosa (Extension of Study RET IRD 01)
214.50 Ko
09/07/2020
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Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis
206.96 Ko
20/07/2020
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Genetic Decryption of Leber Congenital Amaurosis (LCA) in a Large Cohort of Independent Families
199.56 Ko
10/07/2020
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Extension Study to Study PQ-110-001 (NCT03140969)
200.98 Ko
16/07/2020
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Efficacy and safety of QLT091001 in subjects with Inherited Retinal Disease (IRD) caused by gene mutations
233.93 Ko
16/05/2019
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RET-IRD-04
233.93 Ko
16/05/2018
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Genetic Study of Patients Suffering From Congenital Amaurosis of Leber or From an Early Severe Retinal Dystrophy
200.64 Ko
17/09/2020
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A double-masked, randomized, controlled, multiple-dose study to evaluate theefficacy, safety, tolerability and systemic exposure of QR-110 in Subjects withLeber’s Congenital Amaurosis (LCA) due to c.2991+1655A>G mutation (p.Cys998X) in the CEP290 gene (Il
218.39 Ko
09/07/2020
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Study to Evaluate QR-110 in Subjects With Leber’s Congenital Amaurosis (LCA) Due to the c.2991+1655A>G Mutation (p.Cys998X) in the CEP290 Gene
201.73 Ko
09/07/2020
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Genetic Study of Patients Suffering From Congenital Amaurosis of Leber or From an Early Severe Retinal Dystrophy
200.64 Ko
24/07/2020
Stargardt Disease
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A Phase 3 Multicenter, Randomized, Double-Masked Study Comparing the Efficacy and Safety of Emixustat Hydrochloride With Placebo for the Treatment of Macular Atrophy Secondary to Stargardt Disease
216.94 Ko
29/06/2020
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Safety and Efficacy of Emixustat in Stargardt Disease
214.99 Ko
16/07/2020
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Phase I/IIa Study of SAR422459 in Patients With Stargardt's Macular Degeneration (Stargardt's disease)
224.39 Ko
16/05/2018
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Natural History of the Progression of Atrophy Secondary (Stargardt Disease type 4) 2
210.81 Ko
28/11/2018
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Therapeutic Potential of Omega-3 Fatty Acids Supplementation in Dry Macular Degeneration and Stargardt Disease (MADEOS)
211.82 Ko
23/05/2019
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A Study to Determine the Long Term Safety, Tolerability and Biological Activity of SAR422459 in Patients With Stargardt's Macular Degeneration (Stargardt's disease)
224.53 Ko
16/05/2018
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Safety and Tolerability of Sub-retinal Transplantation of Human Embryonic Stem Cell Derived Retinal Pigmented Epithelial (hESC-RPE) Cells in Patients With Stargardt’s Macular Dystrophy (SMD)
208.33 Ko
20/07/2020
Hereditary retinal disease
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Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS
199.88 Ko
16/07/2020
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Cornea Ectasia Excimer Laser Treatment
196.56 Ko
20/07/2020
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CURETINA personalized medicine in hereditary retinal degenerations
209.77 Ko
16/07/2020
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Clinical and Molecular Studies in Families With Inherited Eye Disease
197.07 Ko
20/07/2020
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ReCOVER (This trial does use Clemastine fumarat as a remyelinating agent targeting the muscarinic receptor on oligodendrocytes around the optic nerve)
210.55 Ko
16/05/2019
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Prospective Analysis of «Genotype-phenotype» Correlations Observed in a Large Cohort of Patients With Hereditary Retinal Dystrophies - GEPHIRD
210.42 Ko
09/07/2020
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Phase I Trial of Gene Vector to Patients with Retinal Disease due to RPE65 mutations
199.70 Ko
09/07/2020
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Argus II retinal prosthesis system post- market surveillance study protocol (inherited retinal dystrophy & choroidal dystrophy) - Copie
260.69 Ko
24/07/2020
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Nanometer-controlled cut-off filters in real-life self-reported quality of vision of patients with retinitis pigmentosa (inherited retinal dystrophy)
251.76 Ko
16/05/2018
Neurotrophic Keratitis
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Evaluation of safety and efficacy of r-hNGF (Neurotrophic Keratitis)
211.29 Ko
28/11/2018
CNGA3-linked achromatopsia
Argus II
Argus® II Retinal Stimulation System Feasibility Protocol (retinotosis pigmentosa) 2 - Copie
212.46 Ko
24/07/2020
Argus® II Retinal Prosthesis System: Post-Market Study - Copie
200.83 Ko
24/07/2020
Self-confidence Study in Patients With Argus II Artificial Retina Rare Eye
198.42 Ko
10/07/2020
Argus II retinal prosthesis system post- market surveillance study protocol (inherited retinal dystrophy & choroidal dystrophy)
260.69 Ko
24/07/2020
Glaucoma
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Long-Term Non-Interventional Latanoprost Study
270.68 Ko
05/07/2018
Usher Syndrome
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Light4deaf study: study of the natural history of the syndrome of usher in a cohort of patients followed longitudinally for 5 years (Usher Syndrome)
224.37 Ko
16/05/2018
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Rush2A
249.81 Ko
08/11/2018
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Natural History Study in Subjects With Usher Syndrome 2
195.96 Ko
20/07/2020
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Clinical and Genetic Examination of Usher Syndrome Patients’ Cohort in Europe
200.22 Ko
10/07/2020
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Open-Label Study to Determine the Long-Term Safety, Tolerability and Biological Activity of UshStat® in Patients With Usher Syndrome Type 1B (Usher Syndrome)
225.23 Ko
16/05/2018
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VITAL (USHER syndrome induced by MYO7A mutation and retinotosis pigmentosa) - Copie
239.78 Ko
24/07/2020
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Study to Evaluate Safety and Tolerability of QR-421a in Subjects With Retinitis Pigmentosa Due to Mutations in Exon 13 of the USH2A Gene (Stellar) - Copie
211.63 Ko
24/07/2020
Bardet-Biedl
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Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in Adults
201.36 Ko
10/07/2020
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Treatment of Bardet-Biedl-Syndrome With Metformin for Evaluation of a Possible Visual Improvement
202.18 Ko
16/07/2020
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Setmelanotide (RM-493), Melanocortin-4 Receptor (MC4R) Agonist, in Bardet-Biedl Syndrome (BBS) and Alström Syndrome (AS) Patients With Moderate to Severe Obesity
204.17 Ko
29/06/2020
Alström Syndrome
Chorioretinopathy
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SPECTRA trial (central serous chorioretinopathy) 2
207.19 Ko
20/07/2020
Keratoconus
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Measurement of High Order Aberrations in Late Stages Keratoconus
199.80 Ko
16/07/2020
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Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients
196.90 Ko
20/07/2020
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Transepithelial Corneal Collagen Crosslinking in Eyes With Progressive Keratoconus
199.47 Ko
16/07/2020
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Iontophoretic Transepithelial Collagen Cross-linking Versus Epithelium-off Collagen Cross-linking in Pediatric Patients. Three Year Follow up.
197.63 Ko
20/07/2020
Congenital cataract registry
Ichthyosis
Trisomy 21
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Trisomy 21 in Adulthood : a medical and social situation in Alsace
227.20 Ko
13/06/2018
Other
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High resolution and high speed Multimodal Ophthalmic Imaging (IMA-MODE)
200.21 Ko
29/06/2020
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High Resolution Retina Imaging (IHR) Rare Eye
198.46 Ko
29/06/2020
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A Study to Determine the Safety and Efficacy of Renexus® in Macular Telangiectasia Type 2
202.20 Ko
16/07/2020
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Advanced Characterization of Autosomal Dominant Optic Atrophy
200.96 Ko
09/07/2020
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Interest of Intravitreal Injections of Anti-VEGF as Initial and Adjuvant Treatment in Coats Disease
202.89 Ko
16/07/2020
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EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment
199.09 Ko
20/07/2020
Search for a Clinical trial
Clear search
Retinal Rare Eye Diseases (WG1)
NCT01496040
Retinitis Pigmentosa, Pediatric clinical trials
Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65
Leber Congenital Amaurosis
2013-005393-22
Retinitis Pigmentosa, Pediatric clinical trials
NCT02994368
Choroideremia, Pediatric clinical trials
A Multicenter Prospective Observational « Natural History » Study in Patients With Choroideremia
RSFVEN-330/2010
Retinitis Pigmentosa
Retinitis pigmentosa: molecular diagnosis by next generation sequencing
RET RP 01 - NCT01543906
Retinitis Pigmentosa
NCT03561922
Hereditary retinal disease
Impact on Daily Life of Patients Using the Subretinal Implant RETINA IMPLANT Alpha AMS
NCT02771236
Hereditary retinal disease, Pediatric clinical trials
Clinical and Molecular Studies in Families With Inherited Eye Disease
NCT01496040
Leber Congenital Amaurosis, Pediatric clinical trials
Clinical Gene Therapy Protocol for the Treatment of Retinal Dystrophy Caused by Defects in RPE65
Leber Congenital Amaurosis
EST_2 - NCT01837901
Retinitis Pigmentosa
Transcorneal Electrostimulation for Therapy of Retinitis Pigmentosa
NCT02890550
Alström Syndrome, Pediatric clinical trials
NCT03746522
Bardet-Biedl, Alström Syndrome, Pediatric clinical trials
NCT02860520
Retinitis Pigmentosa, Pediatric clinical trials
NCT01505062
Retinitis Pigmentosa, Usher Syndrome, Pediatric clinical trials
Study of UshStat in Patients With Retinitis Pigmentosa Associated With Usher Syndrome Type 1B
NCT02759952
Retinitis Pigmentosa
NCT00515814
Retinitis Pigmentosa
NCT00643747
Leber Congenital Amaurosis
Safety Study of RPE65 Gene Therapy to Treat Leber Congenital Amaurosis
NCT03140969
Leber Congenital Amaurosis, Pediatric clinical trials
NCT01024803
Retinitis Pigmentosa
Safety and Efficacy of Subretinal Implants for Partial Restoration of Vision in Blind Patients
NCT01235624
Retinitis Pigmentosa, Pediatric clinical trials
NCT01367444
Stargardt Disease
Phase I/IIa Study of SAR422459 in Patients With Stargardt’s Macular Degeneration
NCT00213811
Bardet-Biedl
Bardet-Biedl Syndrome Study: Clinical and Genetic Epidemiology Study in Adults
NCT01793090
Other, Pediatric clinical trials
EPI-743 in Cobalamin C Defect: Effects on Visual and Neurological Impairment
RSFVEN-330/2010-BIS
Retinitis Pigmentosa
Therapeutic management of patients with cystoid macular edema secondary to retinitis pigmentosa
NCT03319849
Other, Pediatric clinical trials
A Study to Determine the Safety and Efficacy of Renexus® in Macular Telangiectasia Type 2
RSFVEN-330/2010-TRIS
Retinitis Pigmentosa
NCT00422721
Leber Congenital Amaurosis
NCT00407602
Other, Pediatric clinical trials
NCT00407602
Retinitis Pigmentosa, Pediatric clinical trials
NCT03814499
Usher Syndrome, Pediatric clinical trials
Neuro-Ophthalmology Rare Diseases (WG2)
NCT01892943
Leber Hereditary Optic Neuropathy (LHON), Pediatric clinical trials
Leber Hereditary Optic Neuropathy (LHON) Historical Case Record Survey
NCT02544217
Leber Hereditary Optic Neuropathy (LHON)
A Phase I, Randomized, Double Blind, Placebo-controlled, Dose-escalating Clinical Trial With KH176
NCT02796274
Leber Hereditary Optic Neuropathy (LHON), Pediatric clinical trials
NCT03717909
Wolfram, Pediatric clinical trials
Pediatric Ophthalmology Rare Diseases (WG3)
Anterior Segment Rare Eye Diseases (WG4)
NCT03661164
Keratoconus, Pediatric clinical trials
Iontophoretic Transepithelial Corneal Cross-linking in Pediatric Patients
Congenital cataract registry, Pediatric clinical trials
NCT03753009
Keratoconus, Pediatric clinical trials
NCT04517903
Keratoconus, Pediatric clinical trials
Low Vision, Daily Life and Patients Groups (TWG5)
Genetic Diagnostics (TWG6)
Registries & Epidemiology (TWG7)
Research (TWG8)
National Integration (TWG9)
CPMS & Digital Medecine (TWG10)
ePag
ERN-EYE Coordinating committee
BBS Guidelines
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